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D-Dimer Rapid Detection Kit

The D-dimer Rapid Test Cassette is used for the qualitative detection of D-dimer in human whole blood, serum and plasma. The test is used as an aid in the assessment and evaluation of patients with suspected disseminated intravascular coagulation (DIC), deep vein thrombosis (DVT), and pulmonary embolism (PE).

 

Acute cardiac ailments can be catastrophic to patient health and warrant urgent diagnosis and intervention. Timely detection of cardiac markers, which are released into the bloodstream after cardiac injury such as a myocardial infarction (MI), can help clinicians in making treatment choices. However, these markers are released within a certain time frame after a MI, thus requiring rapid and sensitive technologies to detect their presence.

 

D-dimer is a protein fragment from the breakdown of a blood clot. Blood clots generally start to slowly break down after they are formed, and this process releases D-dimer into the blood. An elevated D-dimer level is not normal. If you are having significant formation and breakdown of blood clot in your body, D-dimer may be elevated.

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Sources:

1. Gaffney, P.J. D-dimer History of Discovery, Characterisation and Utility of this and other Fibrin Fragments. Fibrinolysis 7 Suppl 2:2-8; 1993

2. Lane, D.A. et al. Characterisation of Serum Fibrinogen and Fibrin Fragments Produced During Disseminated Intravascular Coagulation. Haematology. 40: 609-615; 1978.

3. Scarvelis, D and Wells, P.S. Diagnosis and Treatment of Deep Vein Thrombosis. Can. Med. Assoc. J. 175 (9):1087-92; 2006

4. Bick, R.L. et al. Diagnostic Efficacy of the D-dimer assay in Disseminated Intravascular Coagulation (DIC) Thromb. Res. 65:785-790; 1992.

5. Bick, R.L. et al. Disseminated Intravascular Coagulation: Objective Clinical and Laboratory Diagnosis, Treatment, and Assessment of Therapeutic Response. Semin. Thromb. Hemost. 22(1): 69-88; 1996.

6. Hunt, F.A. et al. Serum Cross-Linked Fibrin (XDP) and Fibrinogen/Fibrin Degradation Products (FDP) in Disorders Associated with Activation of the Coagulation or Fibrinolytic Systems. Br. J. Haematol. 60: 715-722; 1985.

7. Subramanian, R.M. et. al. Does an Immunochromatographic D-dimer exclude acute lower limb deep venous thrombosis? Emer. Med. Austral. 18: 457-463; 2006.

8. Runyon, M.S. et. al. Comparison of the Simplify D-dimer assay performed at the bedside with a laboratory based quantitative D-dimer assay for the diagnosis of pulmonary embolism in a low prevalence emergency department population. Emerg. Med. J. 25:70-75; 2008.