Procalcitonin (PCT) Rapid Detection Kit

The Procalcitonin Rapid Test Cassette (Whole Blood/Serum/Plasma) is a rapid test that qualitative detects the presence of Procalcitonin in whole blood, plasma or serum specimens at the sensitivity of 0.5 ng/mL. The test utilizes a combination of monoclonal antibodies to selectively detect elevated levels of Procalcitonin in whole blood, plasma or serum.

 

The Procalcitonin (PCT) is a peptide hormone mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin, Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock.

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Sources:

1. Müller B. et al.: Calcitonin precursors are reliable markers of sepsis in medical intensive care unit. Crit. Care Med. 2000, 28(4): 977-983

2. Harbarth S. et al.: Diagnostic value of procalcitonin, inter- leukin-6 and interleukin 8 in critically ill patients admitted with suspected sepsis. Am. J. Resp. Crit. Care Med. 2001, 164: 396-402

3. Brunkhorst F.M. et al.: Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis and septic shock. Intensive Care Med. 2000, 26(suppl.2): 148-152

4. Meisner M.: Procalcitonin (PCT) – A new, innovative infection parameter. Biochemical and clinical aspects. Thieme Stuttgart, New York 2000, ISBN: 3-13-105503-0

5. Meisner M. et al.: Procalcitonin – Influence of temperature, storage, anticoagulation and arterial or venous asservation of blood samples on procalcitonin concentrations. Eur J Clin Chem Clin Biochem 1997, 35 (8): 597-601

6. American College of Chest Physicians/Society of Critical Care Medicine: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992, 20: 864-874

7. Morgenthaler N. et al.: Detection of procalcitonin (PCT) in healthy controls and patients with local infection by a sensitive ILMA. Clin Lab. 2002. 48(5-6): 263-70

8. Meisner Metal.:Clinical experiences with a new semi-quantitative solid phase immunoassay for rapid measurement of procalcitonin. Clin. Chem. Lab. Med. 2000, 38(10): 989-995

9. Chiesa C, Panero A, Rossi N, Stegagno M, De Giusti M, Osborn JF, Pacifico L. Clin Infect Dis (1998), 26: 664-672: Re-liability of Procalcitonin Concentrations for the Diagnosis of Sepsis in Critically III Neonates

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