Malaria Rapid Detection Kit

The Malaria Test is rapid lateral flow chromatographic immunoassay for the detection of: pLDH (Plasmodium lactate dehydrogenase) specific to Plasmodium species (Pan) in human blood specimen; Malaria P. falciparum specific histidine rich protein-2 (Pf HRP-II); or for the simultaneous detection and differentiation of HRP-II (Histidine-rich protein II) specific to Plasmodium falciparum and pLDH (Plasmodium lactate dehydrogenase) specific to Plasmodium species (Pan) in human blood specimen as an aid in the diagnosis of Malaria infection.

Malaria is a serious, sometimes fatal, parasitic disease characterized by fever, chills, and anemia and is caused by a parasite that is transmitted from one human to another by the bite of infected Anopheles mosquitoes. There are four kinds of malaria that can infect humans: Plasmodium falciparum, P. vivax, P. ovale, and P. malariae. In humans, the parasites (called sporozoites) migrate to the liver where they mature and release another form, the merozoites. The disease now occurs in more than 90 countries worldwide, and it is estimated that there are over 500 million clinical cases and 2.7 million malaria-caused deaths per year. At the present, malaria is diagnosed by looking for the parasites in a drop of blood. Blood will be put onto a microscope slide and stained so that the parasites will be visible under a microscope.

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Item Code: GCMAL(pf/pan)-402a

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Sources:

1. Leonard K. Basco, Frederique Marquet, Michael M. Makler, and Jacques Le Bras. : Plasmodium falciparum and Plasmodium vivax: Lactate Dehydrogenase Activity and its Application for in vitro Drug Susceptibility Assay. Experimental Parasitology 80, 260-271 (1995)

2. David L. Vander Jagt, Lucy A. Hunsaker and John E. Heidrich: Partial Purification and Characterization of Lactate Dehydrogenase from Plasmodium falciparum. Molecular and Biochemical Parasitology, 4 (1981) 255-264

3. David J. Bzik, Barbara A, Fox and Kenneth Gonyer: Expression of Plasmodium falciparum lactate dehydrogenase in Escherichia coli Molecular and Biochemical Parasitology, 59(1993) 155-166

4. Histidine-Rich Protein II: a Novel Approach to Malaria Drug Sensitivity Testing ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, June 2002, p. 1658°©1664 Vol. 46, No. 6

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