IGFBP-1 Rapid Detection Kit

The IGFBP-1 Rapid Test Strip (Cervical Secretion) is a visually interpreted, qualitative immunochromatographic dipstick test for detection of IGFBP-1 in cervical secretions during pregnancy, which is a major protein marker of the amniotic fluid in a cervical sample. The test is intended for professional use to help diagnose the rupture of fetal membranes (ROM) in pregnant women.

Insulin-like growth factor-binding protein-1 (IGFBP-1) known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP-1 gene. IGF-binding proteins (IGFBPs) are believed to be important in the regulation of fetal and neonatal growth. We previously reported that the profiles of IGFBPs in fetal cord serum (FCS) were dependent on the growth/metabolic status of the fetus. It can be detected in cervical secretions of pregnant women with preterm uterine contractions, and whether their presence predicts an increased risk of preterm delivery. The abundance of insulin-like growth factor-binding protein-1 at the maternal-fetal interface in severely preeclamptic pregnancies suggests that the binding protein may participate in the pathogenesis of the shallow placental invasion observed in this disorder. Low circulating insulin-like growth factor-I and elevated insulin-like growth factor-binding protein-1 levels may contribute to restricted placental and therefore fetal growth.

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Sources:

1. Wadell, G. Laboratory Diagnosis of Infectious Diseases: Principles and Practices. New York: Springer-Verlag, Volume II, 1988: 284-300.
2. WILHELMI I, ROMAN E, SANCHEZ-FAUQUIER A. Viruses causing gastroenteritis. Clin Microbiol Infect. April. 2003, vol.9:247-262
3. Cubitt, WD (1982) Rotavirus Infection: An Unexpected Hazard in Units Caring for the Elderly. Geriatric Medicine Today 1: 33-38
4. Erdemoglu and Mungan T. Significance of detecting insulin-like growth factor binding protein-1 in cervico Cervical secretions: Comparison with nitrazine test and amniotic fluid volume assessment. Acta Obstet Gynecol Scand (2004) 83: 622-626

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